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SUMMARY:New approaches to the modernization of technologies for radiation 
 sterilization of bioimplants
DTSTART;VALUE=DATE-TIME:20220712T101000Z
DTEND;VALUE=DATE-TIME:20220712T103000Z
DTSTAMP;VALUE=DATE-TIME:20260906T201929Z
UID:indico-contribution-261@events.sinp.msu.ru
DESCRIPTION:Speakers: Vladimir Rozanov (Lomonosov Moscow State University)
 \nModern requirements for the quality of bioimplants combine the need to e
 nsure not only the necessary osteoinductive potential\, adequate structure
  and mechanical strength\, but also guarantees the safety of the recipient
  due to the high level of sterility of the plastic material.\nAmong the cu
 rrently used technologies for the sterilization of biomaterials\, radiatio
 n exposures occupy an increasing volume [1]. However\, the presence of pro
 nounced dose-dependent side effects that can lead to deterioration of all 
 of the above vital properties and characteristics of bone implants determi
 nes the need for further improvement of radiation technologies.\nOne of th
 e promising solutions is the development of combined technologies that com
 bine\, along with radiation treatment\, other types of physico-chemical ef
 fects with a pronounced resultant synergism of sterilization action. As th
 e author's research has shown\, one of such promising combinations is two-
 stage treatment (ozone + radiation) [2]. Further development and improveme
 nt of the new technology is carried out in several directions. Firstly\, t
 he optimization of the impact parameters at each of the stages. Secondly\,
  the choice of optimal sources (ozone\, radiation) effects to ensure the q
 uality of manufactured bone implants\, including the characteristics of th
 e surface layer of bone samples [3\,4] (relief\, microarchitectonics\, mec
 hanical characteristics\, elemental composition\, etc.).\nThis research ha
 s been supported by the Interdisciplinary Scientific and Educational Schoo
 l of Moscow University «Photonic and Quantum technologies. Digital medici
 ne».\n\n1.	V.V.Rozanov\, I.V.Matveichuk . Clinical Medicine Almanac\, 47\
 , 7. (2019).\n2.	I.V.Matveichuk\, V.V.Rozanov\, I.K.Gordonova et al. Paten
 t of Russian Federation № 26\n 30464\, (29.07.2016).\n3.	V.V.Krasnov\, I
 .V.Matveichuk\, V.V.Rozanov et al. // Genes and Cells\, V. XIV\, Suppl. P.
 125.(2019).\n4.	Chernyaev A.P.\, Rozanov V.V.\, Beklemishev M.K.\, et  al.
  // Bull. Russ. Acad. Sci. Phys.. 84.11. (2020).\n\nhttps://events.sinp.ms
 u.ru/event/8/contributions/261/
LOCATION: НИИЯФ\, 19к\, ауд. 2-15
URL:https://events.sinp.msu.ru/event/8/contributions/261/
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